Older Instrument: The Malvern Instruments Zen 3600 Zetasizer is capable of measuring the size of dispersed particles and molecules in solution.

New instrument: 

The Malvern Panalytical Zetasizer Advance - Ultra (Red) is newly installed light-scattering system for characterizing particle size, zeta potential, molecular weight, and particle concentration of dispersed particles and molecules in solution. The system combines Dynamic Light Scattering (DLS), Non-Invasive Back Scatter (NIBS), Multi-Angle Dynamic Light Scattering (MADLS), electrophoretic light scattering, and static light scattering technologies for comprehensive particle and molecular characterization.

SPECIFICATIONS

Particle Size

Measurement Principle: Dynamic Light Scattering (DLS), NIBS, and MADLS

Measurement Angles: 173°, 13°, 90°

Size Range: 0.3 nm – 15 µm

Minimum Sample Volume: 3 µL

Zeta Potential

Measurement Principle: M3-PALS electrophoretic light scattering

Size Range: 3.8 nm – 100 µm

Maximum Sample Conductivity: 260 mS/cm

Molecular Weight

Measurement Principle: Static Light Scattering (SLS)

Molecular Weight Range: 300 Da – 20 MDa

Particle Concentration — Red Model

Measurement Principle: MADLS / Mie scattering

Concentration Range: 1 × 10⁸ – 1 × 10¹² particles/mL

SYSTEM

Laser: He-Ne, 633 nm

Detector: Avalanche photodiode

Temperature Control: 0°C – 120°C

Software: ZS Xplorer

KEY APPLICATIONS

• Protein and biomolecule characterization
• Nanoparticle size and concentration
• Lipid nanoparticles (LNPs)
• Virus and viral-vector characterization
• Polymer and colloidal systems
• Zeta potential and stability studies
• Molecular-weight determination